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regions (UL-CDRs) represent a unique structural class with exceptional potential for targeting otherwise inaccessible epitopes. These UL-CDRs feature a distinctive architecture comprising a β-ribbon stalk
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on recent advances in recombinant RNAP production, cryo-EM structural elucidation, and fragment-based screening, the project will integrate fluorine-based NMR spectroscopy with active learning algorithms and
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Supervisors: Prof Manish Tiwari Prof Shervanthi Homer-Vanniasinkam Clinical Partner: The Royal National Orthopaedic Hospital (RNOH) Collaborator: Dr. Priya Mandal – UCL Mechanical Engineering
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library of polymer candidates with varied physicochemical properties (charge, size, structure, biodegradability) Formulate polymer–mRNA nanoparticles and characterise their size, stability, and mucus
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rather than the structured biofilms found in real-world environments. This project investigates how engineered surface topographies influence HGT dynamics, aiming to develop design principles for materials
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treatment outcomes in vulnerable populations. Training and Student Development: The student will receive interdisciplinary training in: Peptide synthesis and structural analysis Advanced mass spectrometry