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Field
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. Our lab applies advanced structural and biophysical methodologies including cryo‑electron microscopy (cryo‑EM), X‑ray crystallography, single‑molecule fluorescence, and enzyme kinetics to elucidate how
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decide the fate of their RNAs - whether to translate, store, or degrade them. Using biochemical reconstitution, fluorescent labeling, and single-molecule imaging, you will explore how molecular machines
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lifetime microscopy and single-molecule localization microscopy, with the aim of enabling dynamic observation of living biological systems and nanostructures. This research lies at the interface of physics
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of the metalloprotease ADAM10 trafficking by tetraspanins in colon cancer, using single-molecule techniques. - Single-molecule biophysics (single-molecule localization microscopies and single-molecule Förster Resonance
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responsible for designing, building, and utilizing single-walled carbon nanotube field effect transistor (SWNT FET) sensors to probe biological phenomena at the single-molecule level. See Turvey et al. (2022
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Student or Postdoc (f/m/d) for the project Theory and Algorithms for Structure Determination from Single Molecule X‑Ray Scattering Images Project description Single molecule X‑ray scattering experiments
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–78 (2024). Reed, Brian D., et al. "Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device." Science 378, 186-192 (2022). Ameta, Sandeep, et al. "Darwinian properties
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that are properly folded and competent for protein translation. Force spectroscopy (optical and magnetic tweezers), single-molecule fluorescence, and bulk biochemical methods will be used to investigate how
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disorder (RBD). Newly discovered molecular targets and disease-associated cellular phenotypes are used as readouts in drug screening approaches, to identify molecules that, after in vitro and in vivo
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based on proton quantum tunneling. The aim is to advance energy-efficient memcomputing technologies that integrate information processing and storage within single molecular systems, with potential