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Research Project Nucleic acids are potent triggers of immune responses. The presence of virus-derived RNA or DNA molecules activates nucleic acid sensors inside the host cell, which stimulates protective
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, including liposome preparations and confocal microscopy. For structural work, single particle cryo-electron microscopy is extensively utilized at the Biological Electron Cryogenic Microscopy Center
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data. We have developed in vivo single-cell CRISPR technologies to screen for dozens of molecular factors in vivo during developmental and disease. These technologies are a game-changer in the speed
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spatial transcriptomics, genomics, or imaging-based methods. Experience with image analysis, single-cell or spatial omics data analysis. Familiarity with machine learning frameworks (e.g. PyTorch
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prodromal cohorts and link them to clinical readouts and α-synuclein reactivity. Use cutting-edge single-cell and immune-profiling approaches, linked to clinical phenotyping, to discover early biomarkers and