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in time and space, from single molecules to native tissue environments. The applicant is expected to have a strong computational focus on innovative development and application of novel data-driven
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confocal to super-resolution imaging, imaging of living cells and small animals. Other facilities include single-cell technologies, small molecule and CRISPR screening, high-throughput sequencing
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CLL pathophysiology by providing survival and proliferation signals. BCR inhibitors targeting key BCR-associated kinases, such as BTK and PI3K delta, are highly effective as single agents in CLL but
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-to-treat infections, avoid the use of unnecessary antiviral therapies, and to discover new molecules capable of specifically targeting the immune response of CMV without increasing the risk of acute
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we will use single molecule biophysical methods like optical tweezers and smFRET, with single particle electron cryomicroscopy (cryoEM) and NMR to develop a comprehensive picture of how apicoplast
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, evo-devo, modelling of gene regulation, protein dynamics, signalling and metabolic pathways, computational morphodynamics, single molecule/cell imaging, systems or synthetic biology, and biophysics
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staff include the dynamics and acclimation of photosynthetic light harvesting, NMR/MRI in soft matter and food science, single-molecule biophysics and imaging, and acclimation responses in photosynthetic
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these processes are altered in disease. This project will use cutting-edge single-molecule technologies to explore the molecular rules governing ER activity. In particular, we will focus on how ER proteins search
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wide range of approaches: protein biochemistry and reconstitution, single-molecule biophysics, proteomics, metabolomics, fungal genetics, evolutionary analysis, mammalian cell culture, and live-cell
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eXtended above 3 µm). This project aims to explore Dy³⁺-doped single crystals and transparent ceramics, which present a very strong potential for the generation of ultrashort-pulse lasers in the mid-infrared