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their anticancer and neuroprotective activities in human cell-based assays. Generate SAR data linking specific enzymatic modifications to pharmacological properties. This PhD project offers extensive research
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. To address these questions, the student will use isogenic SARM1 knock-in human induced pluripotent stem cells (iPSCs) with GoF mutations (E340K, del275-276 and A275V), SARM1 knockout and a homozygous intronic
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BBSRC Yorkshire Bioscience DLA Programme: Human Stem Cell-Based Approaches for Neurotoxicity Testing of Environmental Contaminants (CASE Project) School of Biosciences PhD Research Project
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: Refinement of Stem Cell-Based Strategies for Ischemic Lesion Recovery” (reference: RESCUE #1), funded by the Portuguese Foundation for Science and Technology (FCT) under Call MPr-2023-12, taking place at RISE
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, research is vital to advance diagnosis, treatment and prevention. Our strength is in identifying and designing novel therapeutic strategies that will lead to clinical trials. PhD: 3-4 years full-time; 5
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BBSRC Yorkshire Bioscience DLA Programme: Directing Stem Cell Fate – The Role of Ribosomal RNA Modifications School of Biosciences PhD Research Project Competition Funded Students Worldwide Dr E
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, including single-cell genomics (Wright, Lloyd), sexual selection and reproduction (Wright, Pomiankowski, Hemmings, Wigby), gene editing (Dasmahapatra), experimental approaches (Wigby), and stalk-eyed fly
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BBSRC Yorkshire Bioscience DLA Programme: Genomics and development of an exaggerated sexual trait in stalk-eyed flies School of Biosciences PhD Research Project Competition Funded Students
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BBSRC Yorkshire Bioscience DLA Programme: Tackling ageing in the gut: investigating the contribution of macrophages in the intestinal stem cell niche to gut maintenance and repair School