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structure determination using a) cryo-Electron Microscopy b) cryo-Electron Tomography c) X-ray crystallography 3.Preferably published in techniques mentioned above A job description and person specification
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of Staufen1:RNA complexes in vitro; as well as on gathering detailed information of such assemblies combining light and electron microscopy approaches. Techniques Gene cloning, Protein over-expression
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histological techniques and immunocytochemistry confocal microscopy transmission electron microscopy image analysis using dedicated software (eg Neurolucida for confocal, Neurolucida Explorer, Meta Morph and
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, fluorescence and electron microscopy. Cell analysis – PRC, western blot, flow cytometry, advanced microscopy. References Glycans and extracellular vesicles: https://www.sciencedirect.com/science/article/pii
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flow cytometry, microscopy and single-cell omics. References Maffia P, Mauro C, Case A, Kemper C. Canonical and non-canonical roles of complement in atherosclerosis. Nat Rev Cardiol. 2024 Apr 10. doi
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multidisciplinary team of computer scientists, bioinformaticians, clinicians, and experimental scientists. References Fu X, Sahai E, Wilkins A. Application of digital pathology-based advanced analytics of tumour
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seeks to define the life and cell cycles of N. perurans and Perkinsela in detail using light, fluorescence and electron microscopy. In particular, whether the replication of N. perurans and Perkinsela
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effects of collagen IV mutation in cells. Modification of disease development in animal models Techniques used: State of the art imaging techniques including 3-dimensional electron microscopy, confocal
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the Arabidopsis circadian clock. https://pubmed.ncbi.nlm.nih.gov/37897048 Environmental regulation of plant gene expression – the role of ultraviolet light Supervisor: Gareth Jenkins Project description: Light is a
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and cellular mechanisms shaping spatial and temporal trajectories of liver regeneration and cancer. Linking computer simulations with experimental observations will further uncover intrinsic and