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allow researchers to explore alternative approaches. Target trial emulation is a structured framework to design observational studies that mimic randomized controlled trials, while reducing methodological
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. Randomized controlled trials (RCTs) underpin regulatory and clinical decision-making in healthcare, yet they are primarily designed to estimate average treatment effects within selected samples. This raises
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LISA (https://cesam.cnrs.fr/ ), a world-class facility designed to study aerosols under realistic conditions. The study will target HLD aerosols generated from natural soil samples collected in different
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