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, if the constraint is able to mimic a bioactive conformation, improve potency. We have devised a new asymmetric approach to lactam constrained amino acid building blocks bearing a range of polar and
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on their surface. The principle is that the large hyperbranched polymers will prevent the core collapsing. As such, there will be a large space inside these systems, which will be capable of binding large
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assembled, studies to measure oxygen stability and reversible oxygen binding will then be undertaken. For more information, please contact Dr Twyman (l.j.twyman@sheffield.ac.uk) and see Dr Lance J. Twyman
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