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Supervisor: Dr. Anna Schulten Topic title: Epigenetic silencing mechanisms in plant environmental responses Annotation: Organisms can register and remember environmental signals through mechanisms that sustain
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transcription, leading to a reduction in CD20 expression on CLL cells, which directly impacts the efficacy of anti-CD20 antibodies. We aim to elucidate the mechanisms underlying CD20 regulation in the context
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Seda, Ph.D. Topic title: REGULATION OF CELL MIGRATION IN B CELL LEUKEMIAS AND LYMPHOMAS Annotation: The project goal is to understand the molecular machinery that regulates the migration of malignant B
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the peptide features and molecular mechanisms that enable efficient membrane fusion. The outcomes of this research will advance our understanding of peptide-mediated membrane fusion and provide a framework for
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elucidate the molecular mechanism of protein-mediated membrane fusion, establishing a framework for the rational design of fusogenic proteins. The designed proteins will enable the development of lipid
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MALIGNANCIES Annotation: Transcription factors (TFs) are important regulators of cell growth, development, and hematopoietic cell differentiation. Disrupting the mechanisms that are responsible for the proper
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details of these interactions and conformational alterations. The results will shed light on the fundamental mechanisms of Helicase-Non-canonical nucleic acid interactions, which are essential
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in a highly translational research environment. Open access to CEITEC MU core facilities (https://www.ceitec.eu/core-facilities/ ) with state-of-the-art equipment and experienced staff members. Our
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references: 1) A. Sasukimar et al. Supramolecular covalency of halogen bonds revealed by NMR contact shifts in paramagnetic cocrystals. Chem. Sci. 2025, 16, 20239-20244. https://doi.org/10.1039/D5SC05769H . 2
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targets for therapy. Recommended literature: Zeni and Mraz LncRNAs in adaptive immunity: role in physiological and pathological conditions. RNA Biol. 2021 May;18(5):619-632. https://pubmed.ncbi.nlm.nih.gov