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complementary biophysical assays on G-quadruplex- and i-Motif-forming DNA/RNA sequences to investigate their structural equilibrium, dynamics, and ligand binding interactome in vitro and in the intracellular
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Supervisor: prof. RNDr. Robert Vácha, PhD. Topic title: Overcoming the Endosomal Barrier: Design Principles of Fusogenic Proteins for Lipid Vesicles Annotation: Cancer remains one of the leading causes
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). Due to the composite viscoelastic environment in living cells, the polymorphism is highly complex, featuring dynamic conformational equilibrium between several folded and unfolded sub-populations driven
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NMR spectroscopy has emerged as a unique and powerful approach for probing biomolecular structure, dynamics, and interactions directly within living human cells under near-physiological conditions. It
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), which establishes and maintains transcriptionally silent chromatin states. This PhD project aims to investigate how structural and biochemical features of these Polycomb proteins determine their