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complementary biophysical assays on G-quadruplex- and i-Motif-forming DNA/RNA sequences to investigate their structural equilibrium, dynamics, and ligand binding interactome in vitro and in the intracellular
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fusion and intracellular cargo delivery. Using a combination of coarse-grained molecular dynamics simulations with the Martini force field and complementary biophysical approaches, we will elucidate
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: 10.1038/s41467-023-39181-2 Research area: Computational biophysics, drug delivery, protein design Keywords:Computer simulations, coarse-grained model, molecular dynamics, membrane fusion, fusion protein
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). Due to the composite viscoelastic environment in living cells, the polymorphism is highly complex, featuring dynamic conformational equilibrium between several folded and unfolded sub-populations driven
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NMR spectroscopy has emerged as a unique and powerful approach for probing biomolecular structure, dynamics, and interactions directly within living human cells under near-physiological conditions. It
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this project will be to elucidate how VEL polymerization properties influence epigenetic silencing dynamics in the regulation of cold-induced flowering (vernalization). The research will combine