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to targeted therapy. Recommended literature: Hoferkova E, et al…. Mraz M. Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations
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microenvironmental interactions of CLL. We will decipher the molecular functions of these lncRNAs using biochemical and cellular approaches and via a novel lncRNA knock-out mouse model. We have engineered mice
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/s41580-023-00668-x Wang L.; Wang G.; Mao W.; et al. Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles. Nat Commun 2023, 14, 3366, doi: 10.1038/s41467-023-39181-2 Research area
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. Bio.l 2024, 25, 101–118, doi: 10.1038/s41580-023-00668-x Wang L.; Wang G.; Mao W.; et al. Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles. Nat Commun 2023, 14, 3366, doi
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microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia. Blood Advances 2022 https://pubmed.ncbi.nlm.nih.gov/35358998/ Hoferkova et al. Stromal cells engineered to express T
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molecular and genetic approaches, including plant genetic engineering, with protein biochemistry methods to investigate protein-protein and protein-chromatin interactions and their impact on histone
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literature: Sandova V et al. IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3K delta inhibitor idelalisib. Haematologica. 2021;106(11):2995-2999. https
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in a highly translational research environment. Open access to CEITEC MU core facilities (https://www.ceitec.eu/core-facilities/ ) with state-of-the-art equipment and experienced staff members. Our
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references: 1) A. Sasukimar et al. Supramolecular covalency of halogen bonds revealed by NMR contact shifts in paramagnetic cocrystals. Chem. Sci. 2025, 16, 20239-20244. https://doi.org/10.1039/D5SC05769H . 2
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and data analysis is desirable. Information about the supervisor: 2 PhD students 2 absolvents Supervisor´s personal webpage https://www.ceitec.eu/dalibor-blazek-ph-d/u25918 Research group info https