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Boudny, Ph.D. Topic title: Lymphoid microenvironment models and their use to study targeted therapy and resistance in B cell malignancies Annotation: Chronic lymphocytic leukemia (CLL) cells and indolent
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Research Group leader (UCO: 8725) Consultant: Silvie Trantirkova, Senior Researcher (UCO: 118502), Topic title: Protein in-cell NMR Spectroscopy in 3D Stem Cell-Derived Human Organ Models Annotation: In-cell
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. Annotation: Protein-DNA interactions are critical in cellular processes and genetic instability-related conditions, particularly involving G-quadruplexes (G4) and their complementary C-rich sequences (i-Motif
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receptor (BCR) signaling and B-T cell interactions. Human genome contains large numbers of lncRNAs that can regulate various physiological cellular processes or contribute to the onset or aggressiveness
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: Computational biophysics, drug delivery, protein design Keywords:Computer simulations, coarse-grained model, molecular dynamics, membrane fusion, fusion protein, protein design Funding of the PhD candidate: ERC
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: 10.1038/s41467-023-39181-2 Research area: Computational biophysics, drug delivery, protein design Keywords:Computer simulations, coarse-grained model, molecular dynamics, membrane fusion, fusion protein
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depend on signals in the immune microenvironment. However, the factors that regulate this are mostly unclear. The lab established several models for in vitro and in vivo studies of microenvironmental
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, use of primary samples, and functional studies with various in vitro and in vivo mouse models. The research is also relevant for understanding resistance mechanisms to targeted therapy. Recommended
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primary samples from patients. We will identify functions of ncRNAs using CRISPR interference, RNA pulldown experiments, RNA profiling, mouse models, and molecular biology techniques. This will help better
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biological function in environmental responses using the model plant Arabidopsis thaliana. Building on recent evidence that VEL proteins can form higher-order assemblies through polymerization, a key focus of