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time Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Topic title: RNA REGULATORY NETWORKS IN AGGRESSIVENESS OF B CELL
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for nucleic acid/ protein systems and their complexes with small ligand-like molecules. Familiarity with NMR data acquisition and analysis for characterising dynamics is advantageous. Strong scientific writing
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lymphomas: how a complex biology gets more complex. Leukemia. 2015 May;29(5):1004-17 Research area: Cancer biology Keywords: lymphoma, CLL, lncRNA, microenvironment Funding for the PhD candidate: In
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). Due to the composite viscoelastic environment in living cells, the polymorphism is highly complex, featuring dynamic conformational equilibrium between several folded and unfolded sub-populations driven
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, Bryja V, Geyer M, Blazek D*, Barboric M*. Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex. Nucleic Acids
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complex biological systems. Building on this foundation, the proposed project aims to take a critical step forward by developing and applying in-cell NMR spectroscopy in 3D human organ models derived from
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) J. Novotny et al. Paramagnetic Effects in NMR Spectroscopy of Transition-Metal Complexes: Principles and Chemical Concepts. Acc. Chem. Res. 2024, 57, 1467-1477. https://doi.org/10.1021/acs.accounts
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changes in gene expression. Such memory is provided by epigenetic DNA or histone modifications. In plants, VEL proteins are accessory components to the histone-modifying Polycomb Repressive Complex 2 (PRC2