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, we found that CDK12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes, including BRCA1, and plays a role in cell cycle progression by regulating
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space. The outcome will provide fundamental insights into the dynamic structural interconversion of non-canonical nucleic acid systems, enabling the fine-tuning of gene expression and associated cellular
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. Annotation: Protein-DNA interactions are critical in cellular processes and genetic instability-related conditions, particularly involving G-quadruplexes (G4) and their complementary C-rich sequences (i-Motif
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