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on the structure–function relationship of the bacterial chromosome. How bacteria organize their DNA and how this structure influences gene expression remain open questions. For example: How is the chromosome
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combining CRISPR-based endogenous protein tagging, advanced quantitative imaging, and biochemical approaches, this project seeks to uncover novel principles of replisome plasticity. A key long-term objective
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have a unique gene expression program and atypical chromosome segregation during mitosis; yet, the underlying mechanisms remain elusive. The goals are to elucidate the chromatin structure and associated
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endogenous protein tagging, advanced quantitative imaging, and biochemical approaches, this project seeks to uncover novel principles of replisome plasticity. A key long-term objective is to identify cancer
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on immune cells and hematological malignancies. We aim to understand how changes in genome structure and regulation contribute to the development and progression of leukemia. Our new teammate will be