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”. The main objective of the SPAN network is to address this need by prioritizing the testing of different neuroprotective agents in humans based on their measured comparative efficacy in experimental stroke
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patients, in vivo mechanistic studies (mice), and in vitro human primary cell experiments. Current studies focus on single-cell spatial transcriptomic characterization of the human endothelial response
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with the primary aim of improving health services for Veterans, particularly in the areas of blood pressure control, acute and chronic kidney disease, antibiotic stewardship, and rural Veteran access
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