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cutting-edge technologies to dissect these interactions: high-density microelectrode arrays (HD-MEAs) for large-scale electrophysiology, spatial transcriptomic methods, and human iPSC-derived neuronal
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fish larvae. Although the importance of drift is well established, many of its underlying dynamics—particularly its spatial and temporal variability—remain poorly quantified. This knowledge gap largely
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respond to diverse mechanical cues from their environment, including adhesion, stiffness, tension, shear, pressure, and confinement. These cues are integrated across wide spatial and temporal scales, from
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the tissue response around the materials will be followed by multimodal approaches including (among others) time-lapsed in vivo imaging, multiphoton intravital microscopy, spatial transcriptomics and