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to develop a new generation of fluorescence microscopy methods aimed at overcoming current limitations in acquisition time for single-molecule imaging. The project explores original strategies for temporal
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lifetime microscopy and single-molecule localization microscopy, with the aim of enabling dynamic observation of living biological systems and nanostructures. This research lies at the interface of physics
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LevelPhD or equivalent LanguagesFRENCHLevelBasic Research FieldPhysicsYears of Research ExperienceNone Additional Information Eligibility criteria PhD in experimental physics (atomic physics, optics, lasers
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high-resolution microscopy • Mammalian cell culture and genetic manipulation • Molecular and biochemical assays • Quantitative analysis of intracellular trafficking dynamics The project will be carried
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expertise in macrophage/stroma interactions. Applicants must hold a PhD (or be close to completion: thesis submitted at the time of application) in immunology, stem cell biology, or stromal cell biology
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) the creation of new-based DNA nanostructures as a molecular template to hold proteins to facilitate molecular imaging by single-particle Cryo-Electron Microscopy (Cryo-EM) (2) the development of DNA-based nano
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of the metalloprotease ADAM10 trafficking by tetraspanins in colon cancer, using single-molecule techniques. - Single-molecule biophysics (single-molecule localization microscopies and single-molecule Förster Resonance
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validation. The postdoctoral researcher will work within the Metasurface Team at CRHEA, in close interaction with permanent researchers, postdoctoral fellows, PhD students, engineers, and external
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be studied by cryo-electron tomography and single-molecule fluorescence microscopy. The "Mechanism of chromatin patterning" team is an international and interdisciplinary team belonging to the MCD unit
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validation. The postdoctoral researcher will work within the Metasurface Team at CRHEA, in close interaction with permanent researchers, postdoctoral fellows, PhD students, engineers, and external