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About the Project A fully funded PhD scholarship is available at UCL Electronic & Electrical Engineering (4 years, home tuition fees covered, stipend provided). Exceptional international candidates
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annually, with life-threatening consequences for immunocompromised individuals. With few antifungal drugs available and resistance on the rise, this project explores a novel strategy: engineering the fungal
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
samples. Nanopore technology, which detects molecules via changes in ionic current as they pass through nanometer-scale pores, has revolutionised nucleic acid sequencing and holds untapped potential
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rather than the structured biofilms found in real-world environments. This project investigates how engineered surface topographies influence HGT dynamics, aiming to develop design principles for materials
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Supervisors: Prof Manish Tiwari Prof Shervanthi Homer-Vanniasinkam Clinical Partner: The Royal National Orthopaedic Hospital (RNOH) Collaborator: Dr. Priya Mandal – UCL Mechanical Engineering
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of RFC1 disease. In parallel, we will a gene perturbation analysis using the Crispr-I technology in genetically engineered iPSC-derived sensory neurons to further investigate the effect of GWA loci and to
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engineering, and nanofabrication techniques. Test materials against clinically relevant pathogens such as Pseudomonas aeruginosa and Staphylococcus aureus. Impact and Outlook: This project will deliver a new
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language model (LLM)-based genome design tools with bioprocess engineering to create next-generation therapeutic conjugative plasmids. These engineered plasmids will be optimised for industrial-scale
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(SONATA, EP/V028626/1) and brings together expertise in microfluidics, fluid dynamics, nanoparticle engineering, and dental microbiology. Approach and Methods: Engineer in vitro models of bacterial biofilm
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healthcare settings. Approach and Methods: Synthesize gold nanostars with optimised optical and surface properties for enhanced plasmonic signal amplification Engineer LFA architectures incorporating salt