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(PER1,2,3) and Cryptochrome (CRY1,2) clock proteins, which feedback-repress CLOCK/BMAL1. Within a 24h day, CLOCK/BMAL1 cycles between an active state recruiting co-activators like MLL1, an early repressed
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genetic information into functional proteins, regulating gene expression, and coordinating cellular responses. Like DNA, RNA is vulnerable to chemical damage from endogenous metabolic byproducts and
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RNA-binding proteins (RBPs), such as TDP-43, FUS or TAF15, become dysfunctional in diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer’s disease (AD
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