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lymphomas are known to be dependent on diverse microenvironmental stimuli providing them signals for survival, development, proliferation, and therapy resistance. It is known that CLL cells undergo apoptosis
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literature: Sandova V et al. IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3K delta inhibitor idelalisib. Haematologica. 2021;106(11):2995-2999. https
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MALIGNANCIES Annotation: Transcription factors (TFs) are important regulators of cell growth, development, and hematopoietic cell differentiation. Disrupting the mechanisms that are responsible for the proper
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molecular biology technics. Furthermore, we developed a novel co-culture model inducing robust primary CLL cell proliferation (~50%) in vitro (Hoferkova et al, Leukemia, 2024). We aim to utilize this game
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for understanding resistance mechanisms to BCR inhibitors, pre-clinical development of novel drugs and their combinations (several patents submitted by the lab). Recommended literature: Seda et al….Mraz FoxO1-GAB1
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elucidate the molecular mechanism of protein-mediated membrane fusion, establishing a framework for the rational design of fusogenic proteins. The designed proteins will enable the development of lipid
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holds transformative potential for both basic biomedical research and pharmaceutical development, enabling direct analysis of drug-target engagement, binding affinities, and structural validation in
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modification profiles. This will provide new insights into the gene regulation mechanisms that control plant development and adaptation in response to environmental cues. Understanding how environmental cues