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downstream host consequences. Existing evidence indicates that the oral microbiome is influenced by host genetics and environmental exposures, with their relative importance varying across the life course
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biology, structural biology and chemical genetic approaches, we have elucidated fundamental mechanisms underlying autophagosome formation. Our laboratory has elaborated a novel mode of action for virulent
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host genetics and environmental exposures, with their relative importance varying across the life course. Depending on these upstream factors, oral ecology can shift from eubiosis to dysbiosis, leading
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assays, complemented by mass-spectrometry-driven chemical profiling and machine-learning-supported multivariate analysis. Where relevant, CRISPR-Cas-based genetic perturbations in mammalian cell models
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to career stage and demonstrated expertise in one or more of the following areas: DNA damage and mutagenesis Cancer genomics and sequencing technologies Microbial genetics or toxicology Computational biology