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neurological and developmental involvement. Peroxisomes generate high levels of hydrogen peroxide in their matrix but lack typical protein repair systems such as those found in other subcellular compartments
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Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S) | Portugal | 12 days ago
of Porto, at Salomé Pinho´s lab. Scientific Area: Immunology, Biochemistry, Glycobiology, Carbohydrates, Biophysics 1. Project summary and work plan GLYCOCALYX (https://www.glycocalyx.org/ ) brings together
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Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S) | Portugal | 24 days ago
contains multiple non-coding sequences that activate gene expression partly by RNA-binding proteins (RBPs), in particular USE/iPLUS (doi: 10/nar/gkaf1340.1093; WO/2020/076174) which is particularly relevant
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Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S) | Portugal | about 2 months ago
(methyltransferase, “writers”) and removed by the enzymes FTO or ALKBH5 (demethylase, “erasers”). RNA-binding proteins called “readers”, such as the YTHDF1/2/3 and YTHDC1/2 protein families, recognize and bind to m6A
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Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S) | Portugal | about 2 months ago
proteins, that supports membrane repair; and (iii) assess the impact of repair mechanisms on epithelial barrier integrity and bacterial dissemination. By focusing on host cell repair responses rather than
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, WITHIN THE SCOPE OF THE PROJECT ‘NEW MOLECULES HARNESSING TARGETED PROTEIN DEGRADATION FOR THE TREATMENT OF MACHADO-JOSEPH DISEASE’, (REF. LA CAIXA TARGET-MJD, HR24-00578), OF THE SCHOOL OF MEDICINE AND
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and/or in vivo cardiac function assessment in Molecular Biology (e.g. protein electrophoresis or gel DNA, proteomics, quantitative PCR) or histological analysis (e.g. paraffin tissue preparation
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protein fractionation/extraction and respective physical-chemical and techno-functional characterisation; extraction and characterisation of lipids and chitin/chitosan; development of new food products
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Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S) | Portugal | 3 months ago
/FCT/i3S/2312/2025 A call is opened for the position of a PhD holder, for an unfixed term work contract to carry out research duties within the project “PSGL-1 immune checkpoint protein antibody blockade
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) Experience in analysing the protein fraction of foods and by-products; b) Experience in derivatisation techniques; c) Experience in analysing the prebiotic effect of food matrices. 11. Selection Methods: In