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Curie PhD network centred on mechanobiology, i.e. the study of how physical forces and mechanical cues shape cell physiology. Evidence indicates that key mechanisms of neurodegeneration and cancer
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, you will generate and study human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and engineered cardiac tissues (ECTs). You will develop patient-specific cardiac models to identify
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, with data collection and experimental platforms in place, making a focused and feasible 3‑year PhD trajectory realistic. Most osteoarthritis (OA) patients have inflammation in their affected joints
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neurological diseases pose major challenges to modern healthcare. Despite their apparent differences, these conditions share striking cellular-level similarities, including altered cell–cell communication
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transcription-coupled and other nucleotide excision repair–related DNA repair mechanisms (https://lanslab.eu/publications/ ). This project builds on our previous findings that persistent DNA repair intermediates
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, throughput, latency, and power. Contribute to joint demonstrators and publications with project partners. You will be mentored day-to-day by Dr. Chang Gao (TU Delft) and co-supervised by Prof. Anding Zhu
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genetics projects. Your first project will involve investigating the molecular mechanisms underlying the cell type specificity of Charcot-Marie-Tooth (CMT) disease caused by mutations in tRNA synthetases
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-cell and bulk transcriptomics, mutant screens and transformation approaches to identify signalling pathways and regulatory components. You will analyze data and integrate multi-modal datasets by applying
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: principal investigator dr. Lennart de Nooijer) at the Royal Netherlands Institute of Sea Research (NIOZ) is looking for a highly motivated PhD student with a background in cell biology/ (bio)geochemistry
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group. The project aims to characterize ependymoma tumor cells and its tumor microenvironment (TME) on a single cell level. The goal of the project is to use this knowledge of the immune landscape