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signalling and repair responses, and to evaluate the impact of these processes on proteomic homeostasis. The project is expected to provide fundamental insights into how mechanical signals, DNA damage, and
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, proteomics approaches, as well as immunohistochemistry, fluorescent in situ hybridization (FISH), and confocal imaging. Furthermore, you will use state-of-the-art in vivo noncanonical amino acid tagging (NCAT
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transcription-coupled and other nucleotide excision repair–related DNA repair mechanisms (https://lanslab.eu/publications/ ). This project builds on our previous findings that persistent DNA repair intermediates
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in the analyses that is being generated with the Máxima or by our international collaborators. These include, for instance, in vitro and in vivo experiments, proteomic analyses (spectral-flow cytometry