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Development and application of new methods for studying allosteric regulation in chaperone complexes
and the regulation of protein levels and activities in cells, and the use of the resulting information to design new molecules capable of allosterically regulating these processes. The researcher's work
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. The project will involve the optimization of an experimental workflow, combining in vitro screenings, ex vivo tetramers staining, single-cell RNA sequencing and T cell receptor sequencing, to detect and
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