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stress, e.g. through mechanical agitation or by applying shear forces in microfluidic devices, and will investigate how this impacts phase separation and aggregation of TDP-43, FUS or TAF15 in vitro. We
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generated FUS-eGFP reporter iPSCs for live-cell imaging of RNP granules, facilitating compound screening to identify novel drugs for repurposing as ALS therapeutics. We also generated a microfluidic device
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to identify novel drugs for repurposing as ALS therapeutics. We also generated a microfluidic device enabling the study of axonal RNP granules as well as the functionality of neuromuscular junctions. Here, we
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for live-cell imaging of RNP granules, facilitating compound screening to identify novel drugs for repurposing as ALS therapeutics. We also generated a microfluidic device enabling the study of axonal RNP
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adaptation is crucial for optimal perfusion. In living systems, network architecture constantly changes in response to environmental stimuli towards uniform flow to optimize transport. Combining microfluidic
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or microfluidics and ideally in quantitative data analysis. As a theoretical candidate, you have knowledge in quantitative biology, soft matter/complex systems physics or statistical physics. You enjoy working in
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or comparable degree in physics, biology, bioengineering, material engineering or a related discipline. You have experimental experience in cell/tissue culture, microfluidics, or a related discipline. You enjoy
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? You will grow two-dimensional hydrothermal vents on a microfluidic chip and quantify the vent geometry from your data. You will assess how geochemical mineral composition and inflow rate determine vent