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pathways, pain perception, and tissue alterations in chronic joint disease. Using joint tissues as a biologically and clinically relevant model, the project will explore how stress-related signals interact
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ultrasound, Laboratoire d'imagerie Biomedical, LIB , https://www.lib.upmc.fr/ ) and nanoparticle engineering ( PHENIX Laboratory https://phenix.cnrs.fr/ ). The LIB is located in the Centre de Recherche des
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reached. However, this macroscopic point-of-view ignores the nanoscale spatial heterogeneity of the temperature distribution while strong thermal gradients could induce localized therapeutic effects
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importance through integration in cell membranes, as energy source and in cellular signaling and function. As such, they also play decisive roles in cardiovascular disease, chronic kidney disease, cancer and