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Field
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one of the drivers of cellular transformation and cancer development. Tumor suppressor p53 prevents proliferation of cells with damaged DNA and eliminates them either by programmed cell death or by
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references: 1) A. Sasukimar et al. Supramolecular covalency of halogen bonds revealed by NMR contact shifts in paramagnetic cocrystals. Chem. Sci. 2025, 16, 20239-20244. https://doi.org/10.1039/D5SC05769H . 2
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an innovative research project. • Funding for fieldwork and conference travel. • Fees for open access publications. • Training seminars and workshops to further professional development. • Institutional
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of surfaces or nanostructures and their physical structure, stability, and reactivity. The group employs and, to some extent, develops advanced experimental techniques for the characterization of surfaces, thin
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molecular biology technics. Furthermore, we developed a novel co-culture model inducing robust primary CLL cell proliferation (~50%) in vitro (Hoferkova et al, Leukemia, 2024). We aim to utilize this game
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and plants. It encompasses gamete formation, embryonic development, maturation, growth, reproduction, regeneration, aging, and death. It focuses on processes like cell proliferation, differentiation
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biochemical analyses etc.) within the running project Biocirkl. We prefer candidates with technical skills able to develop various algal cultivation techniques and up-scale. Candidates will be expected
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. Supramolecular covalency of halogen bonds revealed by NMR contact shifts in paramagnetic cocrystals. Chem. Sci. 2025, 16 , 20239-20244. https://doi.org/10.1039/D5SC05769H . J. Novotny et al. Paramagnetic Effects
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cardiomyopathy. Due to the large size of full-length plectin, classical gene-replacement strategies are not feasible, necessitating alternative therapeutic approaches. This PhD project focuses on the development
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of the resulting uracils. Though SHM aims primarily to Ig loci frequent targeting of non-Ig loci was reported accentuating the role of SHM in lymphomagenesis. We developed a series of novel methods providing data