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Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences | Czech | 18 days ago
the design and enzymatic synthesis of hypermodified xeno-nucleic acids with a combination of modifications at the base, sugar moiety and phosphate linkages. After optimization of the methodology, hypermodified
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Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences | Czech | 18 days ago
PROTACs for several kinases, which are validated targets in oncology and in CNS disorders. It will be focused on linker optimization, selection of ligase ligands and specificity for target kinase. Our
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for this programme Detailed information about the study programme Offer of dissertation topics: Healthcare Workforce Optimization in Czechia Considering Population Development Life-Course and Inequalities in
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virtual screening and its optimization and structure-activity relationship studies. The position is funded by a prestigious Junior STAR grant by the Czech Science Foundation. We offer: • Study at
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to methanol. In the first phase, we will engineer PSI and redox enzymes for bioconjugation and optimize the self-assembly process. The stoichiometry will be optimized for efficient light driven reduction
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for relevant problems, to optimize research methods, to process and to interpret the obtained results, and based on the results he/she is able suggest and describe the respective remedy solutions. Application