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and Saeys teams. In this research project you will develop and apply algorithms to link clinical phenotypes of metastasis to molecular phenotypes in mouse models. It is known that metastases exhibit
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microscopy) Flow cytometry Mammalian cell culture (cell models, including iPSC-derived cell lines) Lysosomal immunoprecipitation for multi-omics analysis Chemical synthesis Integration of biochemical, cellular
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effective treatment for these diseases, and the project will entail a search for novel therapies in cell models, which could be moved onto animal models and eventually, affected patients. This will include
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, proteomics, microscopy, structural biology, technology development, and bioinformatics at VIB-UAntwerp Center for Molecular Neurology (https://cmn.sites.vib.be/ ), at VIB (https://vib.be/ ), and at UBirmingham
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research by: 🐟 Developing a smad3 knockout zebrafish model, 🔬 Optimizing in vivo visualization of aortic enlargement and molecular dysfunction, 💊 Developing a pathogenic signalling-based drug screening
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hearing impairment, yet the molecular basis of SNHL remains poorly defined. Using the Nipbl+/- mouse model, this project aims to: - Characterize inner ear development under Nipbl haploinsufficiency
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. Our mission is to move beyond descriptive biology and develop predictive, mechanistic models that connect molecular regulation to cellular and systems-level phenotypes. The Laboratory of Computational
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. Our mission is to move beyond descriptive biology and develop predictive, mechanistic models that connect molecular regulation to cellular and systems-level phenotypes. The Laboratory of Computational
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, technology development, and bioinformatics at VIB-UAntwerp Center for Molecular Neurology (https://cmn.sites.vib.be/ ), at VIB (https://vib.be/ ), and at UBirmingham (https://www.birmingham.ac.uk
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, proteomics, microscopy, structural biology, technology development, and bioinformatics at VIB-UAntwerp Center for Molecular Neurology (https://cmn.sites.vib.be/ ), at VIB (https://vib.be/ ), and at UBirmingham