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the PhD student using technics such as genome editing (CRISPR), RNA sequencing, use of primary samples, functional studies with various in vitro and in vivo mouse models. The research is also relevant
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), which establishes and maintains transcriptionally silent chromatin states. This PhD project aims to investigate how structural and biochemical features of these Polycomb proteins determine their
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novel regulators of the B cell survival, proliferation and crosstalk with other immune cells. The PhD student will further investigate this using techniques such as genome editing (CRISPR), RNA sequencing
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architecture and differentiation contexts. The PhD candidate will develop protocols for isotope labeling, sample handling, and NMR acquisition in stem cell-derived 3D tissues. Recommended literature: Theillet FX
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https://pubmed.ncbi.nlm.nih.gov/36596869/ Research area: Cancer biology Keywords: lymphoma, CLL, lncRNA, microenvironment Funding of the PhD candidate: Part-time salary (min. 0,5 FTE) on EHA grant/AZV