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Title of the project: Genetics of brain diversity in autism The laboratory: Human Genetics and Cognitive Functions Unit (Dir. Thomas Bourgeron) Duration of the contract: 2 years The aim
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with existing single-cell methods and software would represent a strong advantage. Excellent communication skills and team spirit, and an ability to work in autonomy are essential. Fluent English both
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(including proteins and RNAs) simultaneously or quasi-simultaneously in mm- or cmthick samples such as brain organoids. For this purpose, we will develop ‘hyperspectral’ light-sheet imaging approaches with
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experience with existing single-cell methods and software would represent a strong advantage. Excellent communication skills and team spirit, and an ability to work in autonomy are essential. Fluent English
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these approaches, we previously identified an essential role for specific subsets of stromal cells in tissue repair and antitumor immunity (Dulauroy et al., Nature Medicine 2012; Stzepourginski et al., PNAS 2017
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. We will use those nanobodies to identify stable partners of a5 receptors and in parallel we will develop proximity labeling approaches to capture transient partners. Comparison of WT and mutant cells
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. Interestingly, ILC3s also exhibit ‘memory-like’ properties that enhance their protective functions. Despite their presence in intestinal lesions, the contribution of ILC3s to inflammatory bowel disease (IBD
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bacteria The PhD student will work on the impact of the microenvironment of the human gut on colonisation and virulence of enteric bacterial pathogens (EHEC). In this project you will use a highly
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within the AI4AMR consortium, adapt them when necessary, and contribute to improving their performance. Work closely with microbiologists, data scientists, and AI researchers. Implement pipelines for deep
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with host receptors. Complementary biophysical and functional assays will be employed to correlate structure with adhesion mechanisms, providing insights into how bacterial pili assemble, extend, and