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Boudny, Ph.D. Topic title: Lymphoid microenvironment models and their use to study targeted therapy and resistance in B cell malignancies Annotation: Chronic lymphocytic leukemia (CLL) cells and indolent
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Research Group leader (UCO: 8725) Consultant: Anirban Ghosh, Senior Researcher (UCO: 246285), Topic title: Molecular insights into the G-quadruplex–helicase interactome and its functional implications
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time Department: CEITEC MU and Dept of Internal Medicine, Hematology and Oncology Supervisor: RNDr. Josef Večeřa, Ph.D. Topic title: ROLE OF TRANSCRIPTION FACTORS IN ONSET AND PROGRESSION OF B-CELL
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, we found that CDK12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes, including BRCA1, and plays a role in cell cycle progression by regulating
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that are abundant in the human genome and overrepresented in evolutionarily conserved and functionally important regions, including the telomeres, centromeres, and promoter regions of (onco)genes. They have been
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). MicroRNAs were shown to play a pivotal role in B cell functions; however, the functions of long non-coding RNAs (lncRNAs) remain unclear. We aim to decipher for the first time the role of lncRNAs in B cell
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genetic/transcriptional changes and microenvironmental factors are key to improving prognosis and treatment strategies. We aim to decipher for the first time the role of non-coding RNAs (ncRNAs), both
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leukemia (CLL) is the most common leukemia in adults in the Western world. Dysregulation of B cell receptor (BCR) signaling and microenvironmental interactions within immune niches plays a crucial role in
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the PhD student using technics such as genome editing (CRISPR), RNA sequencing, use of primary samples, functional studies with various in vitro and in vivo mouse models. The research is also relevant
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, especially with a focus on heavy element compounds. The Marek Lab has access to state-of-the-art computational tools and cutting-edge NMR instruments at our local core facility, available for regular use. With