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immunological impact on a single cell level In our lab, we have established an integrated toolkit to study myeloid biology at single-cell resolution, combining single-cell sequencing with large, high-dimensional
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CRISPR perturbation of multiple metabolic genes at the single-cell level. - Determining the impact of metabolic gene perturbation on T-cell subsets at different ages by employing single-cell RNA sequencing
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of experimental autoimmune encephalomyelitis (EAE), a mouse model for the human central nervous system (CNS) autoimmune disease multiple sclerosis. We found that when the DCs express the self-antigen in a
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. This mechanism is driven by small non-coding RNAs (piRNAs) that help to guide the effector proteins to their targets in a sequence specific manner. Hence, deciding which RNAs will be turned into piRNAs is a
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sequence written along the string of nucleosomes? How do chromatin material properties are established during the cell cycle? Requirements: We aim at attracting the best talent and expect the following
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hotspots, and they are exceptionally beautiful. We will use a combination of molecular tools, quantitative genetics, and population genetic modelling to study genetic diversity in DNA sequence and phenotype
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employer in our industry. At UKE, we believe that meaningful and successful work should align with our employees' personal needs and individual lifestyles. Just as diverse as these needs are, so too is the
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interdisciplinary, and there are multiple aspects to it that one or two different persons can fill with different interests/backgrounds. In all cases, extensive project training will be provided. Candidates with
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. “Language Models for Oncological DNA Sequence Analysis (LAMOSA)” (working group of Dr Sören Lukassen) 6. “Population-omics to Inform Personalised Drug Prescriptions” (working group of Prof. Maik
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, sample and data analysis and write-up of results for scientific publication are part of the PhD process – a journey to become an independent researcher! Throughout the project, there will be multiple