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immunological impact on a single cell level In our lab, we have established an integrated toolkit to study myeloid biology at single-cell resolution, combining single-cell sequencing with large, high-dimensional
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CRISPR perturbation of multiple metabolic genes at the single-cell level. - Determining the impact of metabolic gene perturbation on T-cell subsets at different ages by employing single-cell RNA sequencing
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of experimental autoimmune encephalomyelitis (EAE), a mouse model for the human central nervous system (CNS) autoimmune disease multiple sclerosis. We found that when the DCs express the self-antigen in a
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. This mechanism is driven by small non-coding RNAs (piRNAs) that help to guide the effector proteins to their targets in a sequence specific manner. Hence, deciding which RNAs will be turned into piRNAs is a
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sequence written along the string of nucleosomes? How do chromatin material properties are established during the cell cycle? Requirements: We aim at attracting the best talent and expect the following
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interdisciplinary, and there are multiple aspects to it that one or two different persons can fill with different interests/backgrounds. In all cases, extensive project training will be provided. Candidates with
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, sample and data analysis and write-up of results for scientific publication are part of the PhD process – a journey to become an independent researcher! Throughout the project, there will be multiple
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of research while interacting with colleagues from multiple disciplines and cultures? Then joining the IPP is your opportunity to give your scientific career a flying start! All you need is: Master or
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imaging over multiple generations. In parallel we will build upon our new experimental and computational framework that links phenotype to function at the single-cell level (named “Look-Seq2”). Strong
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the IPP appcliation platform. Qualification profile: Are you an ambitious scientist looking to push the boundaries of research while interacting with colleagues from multiple disciplines and cultures? Then