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approach combining cryo-electron microscopy, NMR spectroscopy, and advanced molecular modeling, the research will unravel the molecular architecture and conformational dynamics of pili and their interactions
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. In particular, the research project will focus on inferring trajectories from spatial transcriptomics data modelling at the same time the cells evolution in gene expression and in space. Required
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physiological human colon model, combining patient-derived colonic organoids with organ-on-chip (OoC) and enabling to modulate the key gut environmental cues: mechanical stimulation (peristalsis and shear stress
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