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disinfectants. With antimicrobial resistance (AMR) on the rise, there is an urgent need for non-antibiotic strategies to prevent and control biofilm formation on medical devices. This PhD project proposes a novel
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Abstract: Medical device-associated infections (MDAIs) are a major clinical and economic burden, particularly in orthopaedics where implant-related infections can lead to severe complications, including
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that suppress resistance gene transfer. Combining biophysics, microbiology, and materials science, the project will generate insights into how physical environments can be harnessed to control AMR. Approach and
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(SONATA, EP/V028626/1) and brings together expertise in microfluidics, fluid dynamics, nanoparticle engineering, and dental microbiology. Approach and Methods: Engineer in vitro models of bacterial biofilm
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techniques Microbiology and molecular biology Enzymology and antimicrobial screening Training will take place across three state-of-the-art laboratories, with opportunities for collaboration, publication, and