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molecule cellular accumulation and compiling a proteome-scale atlas of chemically tractable vulnerabilities. The project will accomplish this by 1) using high-throughput mass-spectrometry and machine
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individuals. iPSC “Village” systems and CRISPR perturbation to experimentally dissect and validate gene function in controlled, scalable cellular models. Advanced computational genomics, machine learning, and
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, machine learning, and causal inference frameworks that link genetic variants to cellular mechanisms and therapeutic opportunities. Our research spans immune biology, cardiac disease, neurodegeneration, and
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