Bioinformatics Analyst (Cheminformatics)

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The University of Miami/UHealth Department of SCCC has an exciting opportunity for a Full Time Bioinformatics Analyst (Cheminformatics) to work the UHealth Medical Campus in Miami, FL 33146.

CORE JOB SUMMARY
The Bioinformatics Analyst works with research staff to extend capabilities in bioinformatics and improve understanding of genetic variation in human health and disease. The Bioinformatics Analyst maintains and
performs analysis with existing pipelines while assisting and benchmarking the development of novel methods.

CORE JOB FUNCTIONS
● Runs and maintains existing next generation data analysis pipelines.
● Assists senior bioinformatics analysts in pipeline and algorithm development and validation.
● Extracts features of interest from data relating to specific biological questions.
● Contributes to the maintenance of genomic and clinical databases.
● Performs statistical and integrative data analysis on genomics and clinical data.
● Works along-side other team members and data analysts.
● Follows standard operating procedures, documentation, and scripts to generate reports.
● Adheres to University and unit-level policies and procedures and safeguards University assets.
This list of duties and responsibilities is not intended to be all-inclusive and may be expanded to include
other duties or responsibilities as necessary.

CORE QUALIFICATIONS
Education:
Bachelor's degree required. PhD degree in relevant field preferred

Experience:
Minimum 1 year of relevant experience

Knowledge, Skills and Attitudes:
● Skill in collecting, organizing, and analyzing data.
● Ability to recognize, analyze, and solve a variety of problems.
● Ability to exercise sound judgment in making critical decisions.
● Ability to process and handle confidential information with discretion.
● Proficiency in computer software.

Department Specific Functions & Qualifications

The Sylvester Comprehensive Cancer Center & the Department of Molecular and Cellular Pharmacology are actively seeking a full-time Bioinformatics / Cheminformatics Analyst to work on the UHealth campus in Downtown Miami. At Sylvester, we are at the cutting edge of healthcare innovation, leveraging artificial intelligence and machine learning to transform drug discovery and development. Our mission is to accelerate the delivery of therapeutic solutions to patients through state-of-the-art technology and groundbreaking research. The Analyst will leverage expertise in computational chemistry, bioinformatics, and AI to process and analyze large-scale biomedical, small molecule bioactivity, structural biology, image, and clinicogenomic datasets, integrating them with the Sylvester Data Portal. The successful candidate will work within an interdisciplinary team of research scientists, data engineers, and full-stack developers, using state-of-the-art software development practices to enhance the university’s research activities.

Primary Responsibilities:
● Process and analyze large-scale multi-omics and drug discovery datasets (WES, WGS, bulk/single-cell
RNA-Seq, ATAC-Seq, Drug Screening, CRISPR Screening).
● Develop and maintain production-grade pipelines for processing and analysis of diverse biomedical datasets.
● Develop visualization and bioinformatic analysis tools for exploring diverse biomedical data.
● Integrate developed tools and pipelines with Sylvester’s internal end-user data analytics platform.
● Apply state-of-the-art AI, bioinformatics, and biostatistics approaches to cancer precision medicine.
● Write standard operating procedures and other relevant documentation.
● Develop and apply AI/ML models for structure-based and ligand-based drug design.
● Utilize computational tools to predict and optimize pharmacokinetic (PK) and pharmacodynamic (PD) properties
of drug candidates.
● Design and implement algorithms to identify novel drug candidates and elucidate their mechanisms of action.
● Integrate and analyze large-scale biological, chemical, and clinical datasets to extract insights and inform drug
discovery decisions.
● Collaborate with cross-functional teams to advance drug discovery projects.
● Analyze and interpret PK/PD data using advanced statistical and modeling software.
● Stay updated with advancements in computational chemistry, AI, and bioinformatics.
● Contribute to the development of new computational tools and methodologies.
● Present findings to both technical and non-technical stakeholders.
● Participate in scientific discussions and strategy meetings, providing AI/ML expertise.
● Author scientific papers, reports, and patents related to AI/ML in drug discovery.

Preferred Requirements
● PhD or MSc degree in computational chemistry, computational biology, medicinal chemistry, pharmaceutical
sciences, computational sciences, or a related field.
● Fluency in R or Python and Unix (bash).
● Experience with analyzing and interpreting different omics and/or drug discovery datasets (WES, WGS,
bulk/single-cell RNA-Seq, ATAC-Seq, Drug Screening, CRISPR Screening).
● Experience with using common open-source bioinformatics/NGS workflows (BWA, STAR, Picard, GATK, etc.).
● Familiarity with machine learning frameworks (e.g., Scikit-learn, TensorFlow, PyTorch), and developing and
deploying machine learning models.
● Highly motivated, strong work ethic, and able to work independently and with a team.
● Excellent skills in communication, organization, and time management.

Preferred Qualifications
● For Ph.D. holders: 0-3 years of relevant experience in computational chemistry, AI, and drug discovery.
● Deep expertise with chemical toolkits such as DeepChem, ChemAxon, OEChem, or RDKit.
● Familiarity with drug discovery databases (CTRP, GDSC, PRISM, CCLE, DepMap, LINCS) and publicly available
clinicogenomic datasets (CPTAC, TCGA, AACR Project GENIE, etc.).
● Experience with Cloud Computing Environments (e.g., Azure).
● Familiarity with relational (e.g., PostgreSQL) and/or NoSQL databases (e.g., MongoDB).
● Familiarity with container technologies (e.g., Docker).
● Experience with Generative AI tools and techniques.
● Familiarity with High Performance Computing.
● Familiarity with version control (Git).

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The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

The University of Miami is an Equal Opportunity Employer. Applicants and employees are protected from discrimination based on certain categories protected by Federal law.

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