Postdoctoral Researcher in Human Neurovascular Cell Models

University of Oxford, United Kingdom

Updated: about 2 months ago
Location: Oxford, ENGLAND
Deadline: 10 Dec 2025

The postholder will join the Cader Lab at the Kavli Institute for Nanoscience Discovery, University of Oxford, to lead experimental work for one of the key workpackages of the EU Innovation Council SECURE project, a major multi-partner programme developing self adaptive gene therapies for neurological disease.

This will involve (1) producing a single nuclei atlas of the substantia nigra and (2) developing and applying advanced human iPSC-derived blood–brain barrier (BBB) models to evaluate next-generation CNS-targeted viral vectors. The successful candidate will use models to assess vector transcytosis and tropism in both healthy and disease contexts. The work will generate human-relevant data on BBB permeability, receptor expression and transcriptomic signatures that will directly inform AI-driven viral vector design within the SECURE consortium.

This is an exceptional opportunity for a motivated postdoctoral scientist to contribute to a transformative gene therapy platform and to work at the interface of stem-cell biology, neurovascular physiology and translational therapeutics. The postholder will benefit from the Cader Lab’s extensive expertise in iPSC modelling, neurovascular systems, and multi-omics profiling, and will collaborate closely with academic and industrial partners across Europe.

Please see the below 'Job Description' for further details on the responsibilities and selection criteria, as well as further information about the university and how to apply.

The post is full time for a fixed term until 31st January 2029 in the first instance.

Only applications received before 12.00 midday on Wednesday 10th December 2025 will be considered.

Interview will be held in early January 2026. 


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