postdoctoral position M/F in biomolecules molecular dynamics simulations

CNRS, France

Updated: 4 days ago
Location: Lyon 07, RHONE ALPES
Job Type: FullTime
Deadline: 16 Feb 2026

26 Jan 2026
Job Information
Organisation/Company

CNRS
Department

Laboratoire de chimie
Research Field

Chemistry
Biological sciences
Pharmacological sciences
Researcher Profile

First Stage Researcher (R1)
Application Deadline

16 Feb 2026 - 23:59 (UTC)
Country

France
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

35
Offer Starting Date

1 Apr 2026
Is the job funded through the EU Research Framework Programme?

Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

This postdoctoral contract is based on the Emergence HisModSim project obtained by Natacha Gillet at the Laboratoire de Chimie of the ENS de Lyon. It focuses on the impact of post-translational modifications or histone variant modifications in the nucleosome, the primary unit of chromatin, using classical all-atom molecular dynamics simulations. The nucleosome is composed of a double-stranded DNA fragment wrapped around a protein core consisting of eight histones. These proteins are highly conserved in living organisms but can undergo post-translational modifications that can tune gene activation, replication, DNA repair, etc. In addition, histone variants can be exchanged and associated with biological processes such as the circadian rhythm. The aim of the project is to understand at a molecular level the impact of these modifications on the structure and dynamics of the nucleosome, more specifically in the context of oxidative DNA damage and circadian rhythm regulation, in collaboration with IGFL.

The post-doctoral researcher will:
- run a large data set of classical molecular dynamics simulations of modified nucleosomes
- analyze the large data set obtained using various analysis tools, from visualization to automation using machine learning tools
- perform QM/MM calculations on specific aspects
- keep up to date with the literature on both methodological and molecular biology aspects
- communicate the results at conferences and through scientific articles

The research will be carried out within the Theoretical Chemistry and Molecular Thermodynamics axis of the Laboratoire de Chimie ENS Lyon. Our group covers several topics in theoretical and computational chemistry (static and dynamic photochemistry, heterogeneous catalysis, modeling of interfaces and ionic liquids). It benefits from access to the CBPSMN mesocenter, with a large amount CPUs and GPUs facilities. In addition, computing time on national centers (GENCI) is allocated for this project.


Where to apply
Website
https://emploi.cnrs.fr/Candidat/Offre/UMR5182-NATGIL-001/Candidater.aspx

Requirements
Research Field
Chemistry
Education Level
PhD or equivalent

Research Field
Biological sciences
Education Level
PhD or equivalent

Research Field
Pharmacological sciences
Education Level
PhD or equivalent

Languages
FRENCH
Level
Basic

Research Field
Chemistry
Years of Research Experience
None

Research Field
Biological sciences
Years of Research Experience
None

Research Field
Pharmacological sciences
Years of Research Experience
None

Additional Information
Eligibility criteria

Candidates must have experience in computational chemistry. Expertise in classical molecular dynamics simulations, preferably on biological systems, is expected. Programming and/or machine learning skills will be appreciated.


Website for additional job details

https://emploi.cnrs.fr/Offres/CDD/UMR5182-NATGIL-001/Default.aspx

Work Location(s)
Number of offers available
1
Company/Institute
Laboratoire de chimie
Country
France
City
LYON 07
Geofield


Contact
City

LYON 07
Website

http://www.ens-lyon.fr/CHIMIE

STATUS: EXPIRED

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