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Medicine Supervisor: Mgr. Veronika Šandová, Ph.D. Topic title: Therapy-induced changes in CD20 expression and microenvironmental interactions in chronic lymphocytic leukemia Annotation: Chronic lymphocytic
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Medicine Supervisor: Prof. Marek Mraz, MSc., M.D., Ph.D. Topic title: Long non-coding RNAs (lncRNAs) in microenvironmental interactions of B cell chronic lymphocytic leukemia Annotation: Marek Mraz research
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. Annotation: Protein-DNA interactions are critical in cellular processes and genetic instability-related conditions, particularly involving G-quadruplexes (G4) and their complementary C-rich sequences (i-Motif
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labelling strategies (chemical, enzymatic synthesis, click chemistry basics) Complementary expertise in other biophysical assays to monitor biomolecular interactions/binding affinities (i.e. ITC, MST, BLI
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LYMPHOMAS Annotation: Marek Mraz research group has a long-term interest in non-coding RNAs and microenvironmental interactions of malignant B cells, and this research has been supported by an ERC Starting
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NMR spectroscopy has emerged as a unique and powerful approach for probing biomolecular structure, dynamics, and interactions directly within living human cells under near-physiological conditions. It
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interactions and their interplay (Hoferkova et al, Leukemia, 2024; Pavlasova et al. Blood, 2016; Pavlasova et al. Leukemia, 2018; Musilova et al. Blood, 2018; Mraz et al. Blood, 2014; Cerna et al. Leukemia, 2019
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molecular and genetic approaches, including plant genetic engineering, with protein biochemistry methods to investigate protein-protein and protein-chromatin interactions and their impact on histone