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the mechanisms of neurovascular coupling (NVC) in the human retina — a key physiological process whose early dysfunction is linked to Alzheimer's disease. The team has developed a new cellular-resolution imaging
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Eligibility criteria - physics with knowledge in optics - knowledge in microscopy - knowledge in single-molecule imaging (acquisition and processing) - knowledge in photophysics - knowledge in cell culture
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conduct in vivo experiments to investigate retinal neurovascular dynamics using the AO-RSO system; Develop or adapt high-speed image acquisition and processing methods for simultaneous measurement
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modality for single-molecule localization. The main responsibilities will include: -designing and developing the optical instrumentation, -adapting and extending existing image and data processing tools
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lie at the crossroads of multiple disciplines and involve expertise in optics, electronics, image and data processing (including machine learning), photophysics, chemistry and biology. The position is
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expertise in quantitative biophysics and/or modeling approaches. • Experience in advanced imaging, quantitative data analysis, and image processing. • Ability to develop interdisciplinary approaches
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origins (bacterial, biological fluids, hybrid nanovectors, etc.). He/she will develop protocols for fluorescent labeling (e.g. DNA paint...), immunolabeling, immunoimmobilization, acquisition, processing
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compatible with high-speed imaging over long durations, (2) optimize system control and develop signal processing tools, and (3) apply it to imaging challenges involving organoids and living biological tissues
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coupled neuronal and vascular dynamics of the human retina. Scientific Objective The goal of this PhD project is to develop new optical methods and advanced image-processing approaches to simultaneously
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vivo experiments to investigate retinal neurovascular dynamics using the AO-RSO system; Developing or adapting high-speed image acquisition and processing methods for the simultaneous extraction