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new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular
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, imaging and dissections. Carry out animal husbandry work, to check the health and welfare of mice and address their welfare needs (including working on weekends on a rota basis) Keep meticulous records
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skills to plan studies across teams, organise workflows and ensure work is completed on time and of high quality. This role is also a critical step in the quality control process, ensuring that day-to-day
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framework. The postholder will be supervised by Dr. Scott (Genomics of Obesity) with support from Dr. Spivakov (Functional Gene Control) and Prof. O’Regan (Computational Cardiac Imaging). More broadly, this
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techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with
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will use computational and imaging approaches to elucidate the genetic and molecular causes of infertility, the impact of aging in male and female fertility, and the effect of metabolism and germline
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multimodal genome-wide datasets to build predictive models of healthy reproductive processes and investigate how these are perturbed in infertility and ageing. The candidate will work closely with other
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pharmacology to deliver key mechanistic and therapeutic insights. The postholder will employ optical tweezers combined with fluorescence imaging to directly visualise nucleic acid sensor interactions with DNA
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will use computational and imaging approaches to elucidate the genetic and molecular causes of infertility, the impact of aging in male and female fertility, and the effect of metabolism and germline