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new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular
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techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with
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will use computational and imaging approaches to elucidate the genetic and molecular causes of infertility, the impact of aging in male and female fertility, and the effect of metabolism and germline
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framework. The postholder will be supervised by Dr. Scott (Genomics of Obesity) with support from Dr. Spivakov (Functional Gene Control) and Prof. O’Regan (Computational Cardiac Imaging). More broadly, this
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multimodal genome-wide datasets to build predictive models of healthy reproductive processes and investigate how these are perturbed in infertility and ageing. The candidate will work closely with other
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will use computational and imaging approaches to elucidate the genetic and molecular causes of infertility, the impact of aging in male and female fertility, and the effect of metabolism and germline
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pharmacology to deliver key mechanistic and therapeutic insights. The postholder will employ optical tweezers combined with fluorescence imaging to directly visualise nucleic acid sensor interactions with DNA