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Cancer Institute/HHMI/Harvard Medical School/Broad Institute- Computational Biology Position in the Kadoch Laboratory Kadoch Laboratory Chromatin and gene regulation in human disease The Kadoch Laboratory
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). We use a combination of developmental biology models including Xenopus (frog), mouse, and pluripotent stem cells, gene editing, and microscopy techniques to investigate the disease genetics and
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. This position will assist with ongoing and expanding research projects involving gene‑edited cavefish and Drosophila. Opportunities to Contribute Assembles, operates, and maintains laboratory and technical
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consequences of its mutation in cancers. Summary aim: This project will investigate the nuclear function of TPL-2 kinase. Techniques: Cell culture, protein-protein interaction studies, CRISPR/Cas9 gene editing
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highly collaborative and interdisciplinary research group within the Department of Genetics. The laboratory studies genome activation, gene regulation, and RNA biology using zebrafish as a vertebrate model
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for collection, verification, statistical analysis, and management of data. Experiments would include cell culture, molecular biology (including gene editing), antibody production and engineering, flow cytometry
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biology techniques including, but not limited to, PCR, protein/DNA/RNA extraction and gel electrophoresis, bacterial transformation, imaging, cloning, gene-editing (such as CRISPR), small and large scale
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in Chlamydomonas using CRISPR-Cas9 gene editing approaches (ii) Spectroscopic characterisation of growth and photosynthesis in the mutant cells (iii) Biochemical purification of tagged complexes. (iv
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cells, 3D vascularized cardioids, CRISPR gene editing, high-throughput CRISPRko/i/a screening, single-cell multiomics, tissue engineering, and animal models. We welcome candidates with expertise in iPSC
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is focused on understanding the mechanisms of cardiovascular development, disease, and regeneration. For more details, please visit our lab website: https://www.nationwidechildrens.org/research/areas