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on the University Hospital Campus Gasthuisberg, where it hosts about 230 researchers and staff, creating a vibrant ecosystem where fundamental research meets clinical practice. What we do Our cells continuously
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potential of genetic discovery. We have access to extensive biosample collections and use advanced omics technologies and genetic-epidemiological methods on human study populations to identify molecular
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of neurodegenerative disorders. The candidate will approach this by: 1) using advanced Brain-on-Chip models to understand how genetic risk affects the function of disease-relevant circuits and eventually use
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and the tumor microenvironment. Synthetic Design: Use sequence-to-function models to design "programmable" synthetic enhancers capable of targeting specific cancer cell states or host cells
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function of disease-relevant circuits and eventually use this knowledge to stratify Parkinson’s disease; and 2) running CRISPR screens on hiPSC-derived neurons and glia to disentangle the complex genetic
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centrosome is essential for early embryonic cell divisions, we still do not understand the profound “centrosome reduction” it undergoes during spermatogenesis and how this pathway impacts embryo development
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on developing and implementing large-scale genome editing tools in plants. We use a variety of systems, from standard knockout, to base editing, prime editing and combinatorial CRISPR screens. Job description We