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application� including: CV Cover letter of maximum 1 page, Arial 11, highlighting your motivation to do a PhD, particularly in the field of repeat expansions/ neurodegeneration, highlighting your future career
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. This project will use large-scale metagenomic mining to uncover novel phage-host associations and identify phage-encoded enzymes, such as endolysins, with antibacterial activity. By integrating evolutionary
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diagnostics, empirical antibiotic use is common, exacerbating resistance. This project aims to develop a next-generation lateral flow assay (LFA) platform for rapid, ultrasensitive detection of RTI pathogens
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infection-resistant implant coatings that do not contribute to AMR. The technology has the potential to reduce infection rates, improve implant longevity, and lower healthcare costs. The approach may also be
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and quorum sensing, offering new strategies to overcome resistance. Approach and Methods: Use cross-linking mass spectrometry to identify peptide targets in mycobacterial membranes Study effects on cell
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that block infection at its source, with broad applicability to respiratory pathogens, including drug-resistant bacteria. Approach and Methods: Use automated synthesis platforms to generate a high-throughput
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approach: integrating mechanical and enzymatic antibiofilm mechanisms into medical-grade polymers to create next-generation single-use medical consumables with built-in, robust antibiofilm properties. By
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) alter resistance mechanisms. Use high-throughput screening and biofilm models to identify conditions that reduce multidrug resistance (MDR). Build a systems-level understanding of how these mechanisms
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the EU who do not have pre-settled status in the UK and shortlisted applicants from overseas countries have the opportunity to apply for an International Scholars Award for Doctoral Training that waives
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targeting AMR gene suppression AI-driven genome design: Use LLM tools (e.g. PlasmidGPT, Evo2) to refactor plasmid genomes for enhanced manufacturability, safety, and performance Microbial validation: Test